Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation.

Tingting Yang, Yiying Wang,Xinyun Cao, Yuting Peng, Jiawan Huang,Li Chen,Jiale Pang,Zhenzhou Jiang,Sitong Qian,Ying Liu,Changjiang Ying,Tao Wang,Fan Zhang,Qian Lu,Xiaoxing Yin

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

The hepatoprotective effect of quercetin on T2DM-associated NAFLD was linked to the restoration of cholesterol homeostasis by the conversion of cholesterol-to-BAs via down-regulating mTOR/YY1 signaling pathway, leading to the increased CYP7A1 activity.

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关键词

Bile acids,CYP7A1,Cholesterol homeostasis,Quercetin,T2DM-associated fatty liver disease,mTOR/YY1 signaling pathway

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