Human EGFRvIII chimeric antigen receptor T cells demonstrate favorable safety profile and curative responses in orthotopic glioblastoma.

Rebecca C Abbott,Melinda Iliopoulos,Katherine A Watson,Valeria Arcucci,Margareta Go,Hannah E Hughes-Parry, Pete Smith,Melissa J Call,Ryan S Cross,Misty R Jenkins

Clinical & translational immunology（2023）

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摘要

This study demonstrates the preclinical functionality of a highly specific CAR targeting EGFRvIII on human cells. This CAR could be an effective treatment for glioblastoma and warrants future clinical investigation.

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关键词

CAR T cells,EGFRvIII,chimeric antigen receptor,glioblastoma,immunotherapy

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