Seborrheic keratosis

Seborrheic keratosis (SK) is the most common benign epidermal tumor in the clinical practice of dermatologists. This review summarizes current knowledge about clinical and histological appearance, epidemiology, pathogenesis and treatment of SK. There are different subtypes of SK based on clinical presentation and histologic findings. Several factors, including age, genetic predispositions, and possibly also exposure to ultraviolet radiation are thought to contribute to the development of SK. The lesions can occur on all areas of the body, except for the palms and soles, but the most common sites are the face and upper trunk. The diagnosis is usually made clinically, in some cases by dermoscopy or histology. Many patients prefer to remove the warts for cosmetic reasons, although there is no medical indication. Treatment options include surgical therapy, laser therapy, and topical drug therapy, which is currently in development. Treatment should be individualized depending on the clinical picture and patient preference.