Ultrasound assisted one-pot synthesis and preliminary in vitro studies of salicylamide arylpiperazines as dual 5-HT1A/5-HT7 ligands

Jolanta Jaśkowska,Anna Karolina Drabczyk,Paweł Śliwa,Przemysław Jodłowski,Edyta Pindelska,Damian Kułaga,Przemysław Zaręba,Zbigniew Majka,Agata Siwek,Małgorzata Wolak,Marcin Kołaczkowski

Journal of Molecular Structure（2023）

引用 4|浏览13

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摘要

•The sonochemical method is effective in the synthesis of long-chain arylpiperazine (LCAP) with high efficiency and purity.•Sonochemical green synthesis of aripiprazole, trazodone and flibanserin.•Ultrasound-assisted synthesis of long-chain arylpiperazine (LCAP) under PTC conditions.•Selective ligands for the 5-HT1A / 5-HT7 receptors.

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关键词

Ultrasound-assisted synthesis,PTC,5-HT,Trazodone,Aripiprazole,Flibanserin,Serotonin receptor ligands,Dual 5-HT1A/5-HT7 ligands,In vitro study,Molecular modeling

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