Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material (vol 146, pg 211, 2023)

Mg (and Mg alloys) and Ti (and Ti alloys) are two important classes of metallic implant materials which are respectively completely degradable and non-degradable after implantation. Making composites com-posed of them offers the promise for combining their property advantages for bone repair. Here, we present a Mg-Ti composite fabricated by pressureless infiltration of pure Mg melt into 3D printed Ti scaf-fold, and demonstrate a potential of the composite for use as new partially degradable and bioactive implant materials. The composite has such architecture that the Mg and Ti phases are topologically bi-continuous and mutually interspersed in 3D space, and exhibits several advantages over its constituents, such as higher strengths than as-cast pure Mg and Ti scaffold along with lower Young's modulus than dense Ti. Additionally, the degradation of Mg phase may induce the formation and ingrowth of new bone tissues into the Ti scaffold to form mechanical interlocking between them; in this process, the Ti scaffold provides constant support and Young's modulus adaptively decreases toward that of bone. Despite the accelerated corrosion than pure Mg, the composite remains non-cytotoxic and does not cause obvious adverse reactions after implantation as revealed by in vitro and in vivo experiments. This study may offer a new possibility for combining mechanical durability and bioactivity in implant materials, and allow for customized and targeted design of the implant.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.