Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling

Young-Sool Hah,Won Keong Lee,Sangyeob Lee,Jin-Hee Seo,Eun Ji Kim,Yeong-in Choe,Sang Gon Kim,Jun-Il Yoo

Journal of Functional Foods（2023）

引用 0|浏览9

暂无评分

摘要

•Coumestrol protects C2C12 myotubes against dexamethasone-induced atrophy.•Coumestrol protects mice against dexamethasone-induced muscle dysfunction.•Coumestrol attenuated dexamethasone-induced atrophy by inhibiting FoxO1/3-mediated protein degradation.•Coumestrol has therapeutic effect on muscle atrophy in dexamethasone-treated muscle atrophy cells and animal model.

查看译文

关键词

Coumestrol,Dexamethasone,Muscle atrophy,FoxO1/3,MuRF1,MAFbx

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要