Therapy-Acquired Clonal Mutations in Thiopurine Drug-Response Genes Drive Majority of Early Relapses in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

Rozy Thakur,Prateek Bhatia,Minu Singh,Sreejesh Sreedharanunni,Pankaj Sharma,Aditya Singh,Amita Trehan

Diagnostics (Basel, Switzerland)（2023）

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摘要

Our study highlights the high frequency of early relapses driven by TA clones, demonstrating the need to identify their early rise during chemotherapy by digital PCR.

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关键词

B-ALL,deep sequencing,relapse,therapy-acquired

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