WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.

Weijing Liu,An Xie,Jing Xiong,Sheng Li,Lin Yang,Weipeng Liu

The journal of gene medicine（2023）

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摘要

WDR3 ubiquitinated USF2 and inhibited its stability, whereas USF2 interacted with promoter region-binding elements of RASSF1A. USF2 transcriptionally activated RASSF1A, which inhibited the carcinogenic effect of WDR3 overexpression.

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关键词

RASSF1A,USF2,WDR3,cancer stem cell,prostate cancer

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