Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents

Xin-Liang Xu,Jin-Xia Lan,Hao Huang,Wei Dai,Xiao-Peng Peng,Sheng-Lan Liu,Wei-Ming Chen,Le-Jun Huang,Jun Liu,Xiao-Jun Li,Jun-Lin Zeng,Xian-Hua Huang, Guan-Nan Zhao,Wen Hou

Bioorganic & Medicinal Chemistry（2023）

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摘要

We report the natural product-based semisynthesis and biological evaluation of novel allosecurinine derivatives among which compound BA-3 displays excellent antitumor activity with good selectivity between cancer cells and normal cells.

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关键词

Allosecurinine,Derivatives,Antitumor,Leukemia

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