The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis

Shouyuan Chi,Suyun Li,Zhiqiang Xu, Guoyu Yang,Yu Song,Zhiwei Liao,Cao Yang,Xinghuo Wu

Biochemical and Biophysical Research Communications（2023）

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摘要

•IDD was associated with pyroptosis, accompanied by the upregulation of DDX3X and NLRP3 expression.•DDX3X expression promotes pyroptosis in NP cells under compression.•DDX3X mediates pyroptosis of NP cells by activating NLRP3 inflammasome.

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关键词

DDX3X,NLRP3,Nucleus pulposus,Pyroptosis,Intervertebral disc degeneration

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