Inhibition of PIM Kinases Promotes Neuroblastoma Cell Differentiation to a Neuronal Phenotype.

Janet R Julson,Colin H Quinn,Laura V Bownes,Sara C Hutchins,Jerry E Stewart,Jamie Aye,Karina J Yoon,Elizabeth A Beierle

Journal of pediatric surgery（2023）

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摘要

Inhibition of PIM kinases differentiated neuroblastoma cancer cells toward a neuronal phenotype. Differentiation is a key component of preventing neuroblastoma relapse or recurrence and PIM kinase inhibition provides a potential new therapeutic strategy for this disease.

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关键词

AZD1208,Neuroblastoma,PIM kinase,Stem cell

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