GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis.

Frontiers in pediatrics（2023）

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摘要

A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.

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关键词

Down syndrome,IGF1,bio-inactive GH,growth hormone,hypothalamus,neurosecretory dysfunction

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