Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming.

Alan Bénard,Frederik J Hansen,Florian Uhle,Bettina Klösch,Franziska Czubayko,Anke Mittelstädt,Anne Jacobsen,Paul David,Malgorzata J Podolska,Anna Anthuber,Izabela Swierzy,Dominik Schaack,Petra Mühl-Zürbes,Alexander Steinkasserer, Michael Weyand,Markus A Weigand,Thorsten Brenner,Christian Krautz,Robert Grützmann,Georg F Weber

Frontiers in immunology（2023）

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摘要

Our study identifies IL-3 as a predictive disease marker for viral reactivation in sepsis and reveals that IL-3 improves antiviral immunity by enhancing the recruitment and the function of pDCs.

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关键词

T cell priming,interleukin-3,plasmacytoid dendritic cells,sepsis,viral pneumonia

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