Primary prophylaxis in children with severe haemophilia A and B-Implementation over the last 20 years as illustrated in real-world data in the PedNet cohorts.

Rolf Ljung, Marloes de Kovel,H Marijke van den Berg

Haemophilia : the official journal of the World Federation of Hemophilia（2023）

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摘要

Primary prophylaxis nowadays starts at an earlier age: before any joint bleed (60% of patients with SHA and SHB). Approximately 70% started on a once-weekly schedule with significantly reduced doses in SHA but unchanged in SHB.

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关键词

factor IX deficiency prophylaxis,factor VIII deficiency,haemophilia A,haemophilia B,neutralizing antibodies

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