Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children.

Kieran J Phelan,Kimberly A Dill-McFarland,Arjun Kothari,R Max Segnitz,Jeff Burkle,Brittany Grashel,Seth Jenkins,Daniel Spagna,Lisa J Martin,David B Haslam,Jocelyn M Biagini,Maninder Kalra,Karen S McCoy,Kristie R Ross,Daniel J Jackson,Tesfaye B Mersha,Matthew C Altman,Gurjit K Khurana Hershey

The Journal of allergy and clinical immunology（2023）

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摘要

These data suggest that the upper airway of frequent exacerbators undergoes peripheral nervous system remodeling, representing a novel mechanism underlying pediatric asthma exacerbation.

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关键词

Asthma,exacerbation,frequent exacerbator,neuronal,pediatric,transcriptomics

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