High- vs. low-dose diclofenac and cardiovascular risks: a target trial emulation.

Morten Schmidt,Lars Arendt-Nielsen,Ellen-Margrethe Hauge,Henrik Toft Sørensen,Lars Pedersen

European heart journal. Cardiovascular pharmacotherapy（2023）

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摘要

Initiators of high- and low-dose diclofenac had comparable increased cardiovascular risks. This finding provides evidence against the assumption that low-dose diclofenac is risk-neutral.

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关键词

cardiovascular disease,diclofenac,dose,nonsteroidal anti-inflammatory drugs

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