IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome.

Benjamin Ng,Chen Xie,Liping Su,Fathima F Kuthubudeen,Xiu-Yi Kwek, Daryl Yeong,Chee Jian Pua,Stuart A Cook,Wei-Wen Lim

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

IL11 causes lung disease in mMFS. This reveals a shared IL11-driven disease mechanism in lung and aorta in MFS and suggests inhibition of IL11 signaling as a holistic approach for treating multiorgan morbidity in MFS.

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关键词

Marfan syndrome,fibrosis,interleukin-11,pathology,pulmonary emphysema

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