Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma.

Hesam Movassagh,Mary Prunicki,Abhinav Kaushik,Xiaoying Zhou,Diane Dunham,Eric M Smith,Ziyuan He,German R Aleman Muench,Minyi Shi,Annika K Weimer,Shu Cao,Sandra Andorf,Amir Feizi,Michael P Snyder,Pejman Soroosh,Elizabeth D Mellins,Kari C Nadeau

Allergy（2023）

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摘要

The specific alterations of monocytes after ambient pollution exposure suggest a possible prognostic immune signature for pediatric asthma, and pollution-induced trained immunity may provide a potential therapeutic target for asthmatic children living in areas with increased air pollution.

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asthma,innate immunity,pediatrics

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