Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models.

Boris Shorning,Neil Trent,David F Griffiths,Thomas Worzfeld,Stefan Offermanns,Matthew J Smalley,Magali Williamson

Cancer research communications（2023）

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摘要

Few therapeutic targets have been identified specifically for preventing locally invasive/oligometastatic prostate cancer from becoming more widely disseminated. Our findings suggest Plexin-B1 signaling, particularly from the clinically relevant mutant, is such a target.

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关键词

prostate cancer,metastasis,mutation

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