Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis.

Zachariah P Schuurs,John P McDonald,Laura V Croft,Derek J Richard,Roger Woodgate,Neha S Gandhi

Frontiers in cellular and infection microbiology（2023）

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摘要

This research presents a starting point for hit-to-lead optimisation, which could lead to inhibition of the SOS response and prevent the acquisition of antibiotic resistance.

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关键词

LexA,antibiotic resistance,covalent inhibitors,molecular docking,proteolysis

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