Parasite and host kinases as targets for antimalarials.
Expert opinion on therapeutic targets(2023)
摘要
We propose priority research areas, including (i) diversification of kinase targets (at present most efforts focus on a very small number of targets); (ii) polypharmacology as an avenue to limit resistance (kinase inhibitors are highly suitable in this respect); and (iii) preemptive limitation of resistance through host-directed therapy (targeting host cell kinases that are required for parasite survival) and transmission-blocking through targeting sexual stage-specific kinases as a strategy to protect curative drugs from the spread of resistance.
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关键词
Malaria,Plasmodium,antimalarial drug,kinase inhibitor,protein kinase
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