Human placental LRP5 and Sclerostin are increased in gestational diabetes mellitus pregnancies.

Anna Papadopoulou,Eirini Thymara,Eirini Maratou, George Kanellopoulos,Vasiliki Papaevangelou,Sophia Kalantaridou,Spyridon Kanellakis,Pinelopi Triantafyllidou,George Valsamakis,George Mastorakos

The Journal of clinical endocrinology and metabolism（2023）

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摘要

Sclerostin and LRP5 were detected in human placentas. The overexpression of placental sclerostin and LRP5 values in GDM compared to non-GDM pregnancies, as well as the positive association of placental sclerostin values with pregestational maternal BMI and maternal fasting glucose concentrations may indicate the development of an adaptive mechanism in face of maternal hyperglycemia.

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关键词

Gestational diabetes mellitus,LRP5,Placenta,Sclerostin,Umbilical sclerostin

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