When Cleaning Facilitates Cluttering – Genome Editing in Ciliates
Trends in Genetics(2023)
摘要
Many organisms remove DNA from their genomes during development. This has foremost been characterized as a means of defending genomes against mobile elements. However, genome editing actually hides such elements from purifying selection, with the survivors evolving approximately neutrally, 'cluttering' the germline genome, enabling it to enlarge over time.
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关键词
genome editing,genome reorganization,transposable elements,epigenetics,germline–soma differentiation,genome defense
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