Fractionated FLASH radiation in xenografted lung tumors induced FLASH effect at a split dose of 2 Gy.

Yuling Dai,Runcheng Liang, Jianxin Wang, Jing Zhang,Dai Wu,Ri Zhao,Zhaoxing Liu,Faguo Chen

International journal of radiation biology（2023）

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摘要

The FLASH effect was successfully reproduced in both single and fractionated irradiation, with 2 Gy being the minimum split dose to achieve the FLASH effect in existing experiments. It is suggested that the transient oxygen depletion might not be the only mechanism behind the FLASH effect.

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关键词

FLASH effect,dose fractionation,oxygen depletion hypothesis,tumor volume,xenografted lung tumor

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