Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies.

Yingjie Qing,Yongjian Guo, Qinwen Zhao,Po Hu,Hui Li,Xiaoxuan Yu,Mengyuan Zhu,Hongzheng Wang,Zhanyu Wang,Jingyan Xu,Qinglong Guo,Hui Hui

Clinical and translational medicine（2023）

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摘要

Collectively, this study suggests targeting lysosomal HSP70-ASM axis by V8 illustrates the great value of drug therapy for T cell malignancies and the unlimited potential of lysosomal targeting for cancer therapy.

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关键词

T cell malignancies,acid sphingomyelinase,heat shock protein 70,lipid metabolism,lysosomal membrane permeabilization,lysosome

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