Characterisation of gut microbiota composition in patients with axial spondyloarthritis and its modulation by TNF inhibitor treatment.

Marie Vallier, Béatrice Segurens,Elise Larsonneur,Vincent Meyer,Stephanie Ferreira, Christophe Caloustian,Jean-François Deleuze,Maxime Dougados,Mathias Chamaillard,Corinne Miceli-Richard

RMD open（2023）

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摘要

Several SpA patients' characteristics modulate the composition of gut microbiota as did TNFi treatment. Moreover, the abundance/prevalence of seven OTUs at baseline may be used as a novel non-invasive index that predicts the response to TNFi with greater accuracy than HLA-B27 status, CRP level and measures of disease activity.

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inflammation,spondylitis, ankylosing,therapeutics,tumor necrosis factor inhibitors

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