Mitochondrial Calcium Nanoregulators Reverse the Macrophage Proinflammatory Phenotype Through Restoring Mitochondrial Calcium Homeostasis for the Treatment of Osteoarthritis.

We demonstrated that METP NPs are effective and highly specific regulators of m[Ca] overload. In addition, we demonstrated that these METP NPs reverse the macrophage proinflammatory phenotype by restoring m[Ca] homeostasis, thereby inhibiting the tissue inflammatory response and achieving a therapeutic effect for OA.