Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality
CHEMICAL COMMUNICATIONS(2023)
摘要
We describe herein an intriguing method for the synthesis of biaryl aldehydes bearing both axial and central chirality through a desymmetric [3 + 2] cycloaddition reaction of activated isocyanides with prochiral biaryl dialdehydes under silver catalysis. This protocol features excellent enantioselectivity, 100% atom economy, good functional group compatibility, and operational simplicity.
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关键词
enantioselective synthesis,aldehydes,biaryl
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