Prevalence of immunoglobulin G and M to SARS-CoV-2 and other human coronaviruses in The Democratic Republic of Congo, Sierra Leone, and Uganda: A longitudinal study

•We found a high prevalence of SARS-CoV-2 receptor binding-domain/nucleocapsid protein binding antibody (IgG/IgM) in the three settings in 2021.•Almost all participants had seroconverted to SARS-CoV-2 by the end of 4 months of follow-up.•Baseline IgG to endemic coronaviruses did not reduce the acquisition of SARS-CoV-2.•Baseline IgG in SARS-CoV-2 predicted higher responses to COVID-19 vaccination.