TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity.

Amira M Badr,Layla A Al-Kharashi,Hala Attia,Samiyah Alshehri,Hanaa N Alajami,Rehab A Ali,Yasmen F Mahran

Pharmaceuticals (Basel, Switzerland)（2023）

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摘要

This study emphasizes that inhibition of TLR4/NLPR3/IL-1β/GSDMD might be a novel mechanism of the nephroprotective effects of NAC or CGA against Cp-induced nephrotoxicity in rats.

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关键词

N-acetylcysteine,NLPR3,TLR4,chlorogenic acid,cisplatin,gasdermin,inflammasomes,nephrotoxicity

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