Supplementary figures from PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells

Suppl. Fig. 1 First-round screening of PI4KIIα inhibitors;Suppl. Fig. 2 Second-round screening of PI4KIIα inhibitors;Suppl. Fig.3. Direct interaction between PI-273 analogs and PI4KIIα;Suppl. Fig. 4. PI-273 resistance screens using CRISPR-Cas9;Suppl. Fig.5. Generate and identify PI4KIIα knock out MCF-7 cells;Suppl. Fig. 6. Effects of PI-273 and its analogs on PI4KIIα downstream signaling pathways;Suppl. Fig. 7. PI4KIIα is required for the regulation of PI-273 on signaling transduction in breast cancer cells;Suppl. Fig. 8. PI-273 inhibits the proliferation of breast cancer cells.;Suppl. Fig. 9 Anti-tumor effect of PI-273 in an MCF-7-induced xenograft model;Suppl. Fig. 10 Inhibitory effect of 100 μM PIK inhibitors on PI4KIIα.