Figure S2. Network representation of Gene Set Enrichment Analysis (GSEA) for Biological pathways. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma

A. Reactome, B. KEGG, C. MYC Pathways, extract from C2 gene sets for ixazomib 24 hours versus control for Jurkat, L540, and L428 cells, with L540 overlaid with either Jurkat or L428. Leading edge analysis with a FDR<0.05 determined significant gene sets enriched for each group. The size of each node reflects the amount of molecules involved for each gene set. The edge thickness (green lines for L540 and blue lines for either Jurkat or L428) represents the number of genes associated with the overlap of two gene sets (or nodes) that the edge connects. Clusters in each grouping were named according to common function. Upregulated gene sets denoted with red color and downregulated gene sets were denoted by blue color.