Supplemental Figures 1-8 from ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors

Supplemental Figures 1-8. Fig. S1. The landscape of mutations of putative ERK1/2 resistance alleles; Fig. S2. Expression and signaling induced by validated ERK resistance alleles; Fig. S3. ERK2 signaling and kinase activity assays with the ERK inhibitor SCH772984; Fig. S4. Analysis of co-mutated ERK1/2 alterations; Fig. S5. Structural localization of RAF/MEK inhibitor alleles; Fig. S6. Drug sensitivity of non-validating alleles; Fig. S7. Drug sensitivity assays of RAF/MEK inhibitor resistance alleles; Fig. S8. Viability of ERK1/2 resistance alleles in WM266.4 cells