Supplementary Figures 1 - 5 from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

PDF file - 579K, S1. Validation of the MDA-MB-435s cell system expressing luciferase gene and expressing or not KCNN3 gene. S2. SK3 knockdown reduced the development of metastases in cancer cell xenograft models. A) SK3 knockdown reduced the metastatic score in cancer cell xenograft model. S3.Role of Orai1 in the constitutive SK3-dependent calcium entry and SK3+ cell migration. S4. Effect of Ohmline on Orai1 and SK3 expression and on constitutive calcium entry. S5. SK3 protein was expressed in smooth muscle cells of urinary bladder detrusor and myometrium and in primary tumour form mice grafted with SK3+ cells 16 weeks post grafted.