Supplementary Methods, Figures 1 - 8 from Selenium Suppresses Leukemia through the Action of Endogenous Eicosanoids

PDF file - 772KB, Supplementary Figure 1. Selenium supplementation abrogates leukemia in a Friend leukemia (FVP) model. Supplementary Figure 2. Effect of selenium supplementation on the splenic histopathology in FVP-infected mice. Supplementary Figure 3. Selenium supplementation increases apoptosis in the spleen of FVP infected mice.Supplementary Figure 4. Essential role of the COX/eicosanoid pathway in the ablation of LSCs in FVP-infected Se-S mice. Supplementary Figure 5. Modulation of expression of NADPH oxidases (A) and Gpx4 (B) by selenium-treatment of BCR-ABL+LSCs. Supplementary Figure 6. Expression of Tp53, Cat and Sod2 in the spleen of FVP-infected mice. Supplementary Figure 7. Activation of p53 in FVP-infected Se-S and MSA mice. Supplementary Figure 8. Selenium-dependent expression of selenoproteins and CyPG synthesis machinery and endogenous production of 12-PGJ2 by LC-MS/MS in BCRABL+ LSCs.