Supplementary Figure 5 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy <i>In Vivo</i>

PDF file - 4.04 MB, DLL4 downregulated the expression of VEGFR3 in human microvascular EC in vitro and in xenograft tumor in vivo. (A). The expression of VEGFR3 at a mRNA level was decreased in human micrcovascular EC (hMEC-1) cultured in vitro after the 24 hour stimulation by recombinant hDLL4 coated on plates, as revealed by qPCR. (B). The expression of mouse VEGFR3 at a protein level was decreased in tumor neovasculature of U87-DLL4 xenografts versus U87-EV xenografts. Mean � SE, N=5. **P<0.01.