Supplementary Figures 1-4 and Supplementary Methods from Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment

Supplementary Figure 1. The rate of proliferation is the same in the orthotopic and transgenic KPC mouse models Supplementary Figure 2. Single c-Met or Hh inhibitor treatment leads to the enhanced expression of the other target and the combination of both c-Met and Hh inhibitors suppresses the expression of both targets more effectively Supplementary Figure 3. Prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to single targeted agents, which can be overcome by the combination of both c-Met and Hh inhibitors. Supplementary Figure 4. Lentiviral knockdown of c-Met in KPC tumor cells results in decrease of Shh expression. Supplementary Materials and Methods