Coupling in-syringe kapok fiber-supported liquid-phase microextraction with flow injection-mass spectrometry for rapid and green biofluid analysis: Determination of antidepressants as an example
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS(2023)
摘要
Quantification of substances in biofluid samples (e.g., urine, blood, and cerebrospinal fluids) are useful for clinical diagnosis. In current study, a rapid and green strategy by coupling in-syringe kapok fiber-supported liquid-phase microextraction with flow-injection mass spectrometry was proposed. The natural kapok fiber was used as an oily extraction solvent (e.g., n-octanol) support material, and an in-syringe extraction device was conveniently constructed. The whole extraction processes, including sampling, washing and desorption, were conveniently conducted by simply pulling/pushing the syringe plunger, enabling rapid analyte enrichment and sample purification. The follow-up flow injection-mass spectrometry detection enabled rapid and high throughput analysis. As an example, the proposed method was applied to analyze antidepressants in plasma/ urine, showing satisfied linearities (R2 >= 0.993) in ranges of 0.2-1000 ng/mL. By employing the in-syringe extraction method prior to flow injection-mass spectrometry detection, the LOQs in plasma and urine were reduced by 25-80 folds and 5-25 folds, respectively. Besides, by employing ethanol and 80% ethanol as the desorption solvent and carrier solvent, respectively, the analytical method showed excellent greenness. In gen-eral, the integrated method provides a promising choice for rapid and green biofluid analysis.
更多查看译文
关键词
Kapok fiber,Supported liquid -phase microextraction,Biofluid,Flow injection,Mass spectrometry,Antidepressants
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要