Urea derivatives of spirocyclic piperidines endowed with antibacterial activity
MENDELEEV COMMUNICATIONS(2023)
摘要
Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test a series of hybrids of spirocyclic piperidine with ureas. Surprisingly, no activity was detected against Mycobacterium tuberculosis. However, significant antibacterial activity was identified and confirmed against common gram-positive as well as gram-negative bacteria.
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关键词
spirocyclic compounds,piperidines,ureas,epoxide hydrolase,membrane transporter Mmpl3,antimycobacterial activity,antibacterial activity
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