Direct and Regioselective C-H Selenylation of 4-Aminocoumarin Derivatives Mediated by Selectfluor (R)

A mild and regioselective approach to the direct selenylation of 4-(N-substituted-amino)-2H-chromen-2-ones employing Selectfluor (R) and diorganyl diselenides has been developed. The reactions were carried out under metal-free conditions, without the need for special devices, and using NaHCO3 as a mild base at room temperature under air. This approach has been suitable for a wide substrate scope affording the 3-selenyl-4-(N-substituted-amino)-2H-chromen-2-ones in good to excellent yields.