[2+2] Cycloadditions of Methylene exo-Glycals: Synthesis of Glycopyranosylidene-Spiro-Azetidine-2-ones (beta-Lactams) and Cyclobutanones
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(2023)
摘要
[2+2] Cycloadditions of methylene exo-glycal derivatives with chlorosulfonyl isocyanate and dichloroketene were studied in detail, investigating the effect of the carbohydrate moiety, protecting groups as well as reaction temperature on the yields of the transformations. These reactions gave new anomeric spiro-beta-lactam and spiro-cyclobutanone derivatives, whose structure was established by 1D and 2D NMR and MS experiments. The transformation of spiro-cyclobutanone into spiro-gamma-lactone was also demonstrated.
更多查看译文
关键词
chlorosulfonyl isocyanate,cycloaddition,dichloroketene,exo-glycal,spiro-cyclobutanone,spiro-beta-lactam
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要