Merging Ullmann-type Cyclization and Ring-Expansion: a Facile Assembly of Pyrimidine-Fused Quinazolinones by Copper Catalysis
Organic chemistry frontiers（2023）
摘要
A copper-catalyzed tandem cyclization reaction of readily available 4-bromoisatins and amidine hydrochlorides has been developed for the first time, enabling the efficient synthesis of pyrimidoquinazolinones in useful yields.
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