Ultrasensitive detection of methamphetamine by antibody-modified transistor assay

Effective detection of methamphetamine(Met)requires a fast,sensitive,and cheap testing assay.However,commer-cially available methods require expensive instruments and highly trained operators,which are time-consuming and labor-in-tensive.Herein,an antibody-modified graphene transistor assay is developed for sensitive and minute-level detection of Met in complex environments.The anti-Met probe captured charged targets within 120 s,leading to a p-doping effect near the graphene channel.The limit of detection reaches 50 aM(5.0×10-17 M)Met in solution.The graphene transistor would be a valu-able tool for Met detection effective prevention of drug abuse.