301. Pro-Myelinating Drugs Promote Functional Recovery in an ASD Mouse Model of Pitt-Hopkins Syndrome

Pitt-Hopkins syndrome (PTHS) is an autism spectrum disorder (ASD) caused by autosomal dominant mutations in the Transcription Factor 4 gene (TCF4). One pathobiological process caused by murine Tcf4 mutation is a cell autonomous reduction in oligodendrocytes (OLs) and myelination. Here, we demonstrate that pro-myelinating compounds are effective at rescuing hypomyelination and behavior in the PTHS mouse model.