19. Excitatory Dysfunction Drives Synchrony Deficits in a Schizophrenia 16p11.2 Duplication iPSC Derived Neuron Model

Euan Parnell,Lorenza Culotta,Marc Forrest,Hiba Jalloul, Blair Eckman,Daniel Loizzo,Marc Dos Santos,Nicolas Piguel,Derek Tai,Hanwen Zhang,Tracy Gertler,Dina Simkin,Alan Sanders,Michael Talkowski,Pablo Gejman,Evangelos Kiskinis,Jubao Duan,Peter Penzes

Biological Psychiatry（2023）

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摘要

Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human iPSC-derived neurons (iNs) has emerged as a promising strategy. Copy number variations (CNV) confer high genetic risk for SCZ, with duplication of the 16p11.2 locus increasing risk 14.5 fold.

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关键词

Human IPSC-Derived Neurons, Receptor Internalization, Single Cell Electrophysiology, Epitope Mapping, Immunoglobulin Class, Serum, Autoantibody Titer, Early Schizophrenia, RNA-sequencing

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