GM-2040 is a Novel Putative Non-Hallucinogenic 5HT2A Agonist With Attenuated Head Twitch and Retained Antidepressant Activity

Adam Klein,Eric Austin,Dino Dvorak,Gerard Marek,Jonathan Sporn,Laszlo Kiss,Zoe Hughes,Andrew Kruegel

Biological Psychiatry（2023）

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摘要

5-HT2A agonists are emerging as potential rapid acting antidepressants. GM-2040, is a novel 5-HT2A agonist with a distinct behavioral signature from hallucinogenic 5-HT2A agonists. Efficacy in a rat model for antidepressant activity and 5-HT2A receptor occupancy were assessed.

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关键词

retained antidepressant activity,attenuated head twitch,agonist,non-hallucinogenic

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