386. Fatty Acid Amide Hydrolase is Associated With Impulsiveness: A Pet Study in Overnight Abstinent Chronic Cannabis Users

Fatty Acid Amide Hydrolase (FAAH) is the enzyme responsible for metabolizing the major endocannabinoid anandamide. FAAH has been linked with addiction-relevant phenotypes including increased impulsiveness, which compromises one’s ability to exert control over drug craving and compulsive drug-use. Here we investigated whether lower brain FAAH levels during early abstinence from cannabis in individuals with cannabis use disorder (CUD), are associated with higher self-reported impulsiveness.