485. Cortical Signatures of Positive and Negative Schizotypy: A Worldwide Enigma Study

Positive and negative schizotypy are associated with impaired neurodevelopment and increased risk for schizophrenia. While cortical morphometric alterations have been associated with both schizotypy dimensions, a comprehensive characterization of shared and dimension-specific neuroanatomical signatures is lacking. Here, we present the first large-scale meta-analyses of cortical morphometric patterns of positive and negative schizotypy in healthy individuals and compare these patterns with neuroanatomical alterations of schizophrenia and neurodevelopmental disorders.