Developmental Phenotypes of Sequential Comorbidity Leading to Major Mood Disorders

Rudolf Uher,Janice Fullerton,Alyson Zwicker,Kathryn Freeman,Elena de la Serna,Josefina Castro-Fornieles,Neeltje van Haren,Manon Hillegers,Frances Rice,Anita Thapar,Lukas Propper,Danella Hafeman,Boris Birmaher,Philip Mitchell,Martin Alda,John Nurnberger

Biological Psychiatry（2023）

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摘要

The onset of major depressive disorder or bipolar disorder is typically not the first manifestations of psychopathology. We examine if sequential comorbidity with attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders separates distinct phenotypes and predicts the onset of mood disorders in the context of family history.

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sequential comorbidity,disorders,phenotypes

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