Patients' IgLON5 autoantibodies interfere with IgLON5-protein interactions.

Jon Landa,Ana Beatriz Serafim,Carles Gaig,Albert Saiz,Inga Koneczny,Romana Hoftberger,Joan Santamaria,Josep Dalmau,Francesc Graus,Lidia Sabater

Frontiers in immunology（2023）

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摘要

We show a potentially novel pathogenic mechanism of IgLON5-abs that consists in blocking IgLON5 interactions with its binding partners. These findings extend our knowledge about the physiological role of IgLON5 and pave the way to future understanding of the pathological mechanisms of anti-IgLON5 disease.

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关键词

IgG4,IgLON5 antibodies,anti-IgLON5 antibody encephalopathy,anti-IgLON5 disease,interactome,neurons

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